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maple syrup urine disease Review Branched-chain Ketoaciduria (Maple Syrup Urine Disease), and Its Effect on the Breakdown of Amino Acids in the Human Body David Holkesvik INTRODUCTION: Branched-chain ketoaciduria, more commonly known as Maple syrup urine disease (MSUD) is a metabolic disorder that causes toxic buildup .Maple syrup urine disease research paper